Customized Medicines

Customized Medicines
Dr. Sonja O'Bryan, Pharm.D., ABAAHP Board Certified Health Practitioner Diplomate-American Academy of Anti-Aging Medicine: "Creative Medicines" for Hormones-Weight-Pain-Fatigue-Skin Diseases-Pediatrics-Autoimmune Disorders-Veterinary Needs. Using Complimentary, Integrative, Regenerative, Bio-Identical, and Lifestyle Medicine For Health and Healing.

Tuesday, May 23, 2017

Health and Technology Predictions: Will A Robot Provide Your Care?

Future Predictions for 2017-2045

Dr Robert Goldman, Co-Founder & Chairman-World Academy of Anti-Aging Medicine, weighs in with his latest set of predictions for health and technology.
It is estimated that the doubling time of medical knowledge in 1950 was 50 years; in 1980, 7 years; and in 2010, 3.5 years. In 2020 it is projected to be 0.2 years—just 73 days. Computer power is doubling every 18 months, so massive increases in scope and scale. Once nanotechnology and nano circuitry, stem cells, and genetic engineering, come on board, the world as we know it will be unrecognizable. Get ready for the first complete synthetic human brain, moon mining, chips implanted in our brains, self-driving cars, trucks and planes, robotic moon bases and maybe even high-speed rail linking London to Beijing.
The most popular movie super heroes demonstrate cellular regeneration like 'Wolverine' allowing mutations to enable rapid cellular repair & healing achieving Immortality, or Captain America in 1942 using Hormone Therapy/Steroid Augmentation to become an athletic Super Hero and with Cryonics/suspended animation freezing him into the 21st century. This Brave New World is coming into being faster than we imagined. To have the great jobs and careers of the future, you must embrace and see it before it arrives.
Radical Life Extension
Billions of dollars have recently flowed into Anti-Aging Medical research, from the likes of Silicon Valley & Biotech Startups chasing after the 'Fountain of Youth', such as Calico (Google), Johnson & Johnson, Human Longevity Inc, Elysium Health, Synthetic Genomics, GlaxoSmithKline / Sinclair, Startup Health, Mayo Clinic, Scripps Research, Roche , Novartis (Rapamycin), AstraZeneca, AbbVie, Pfizer, Sanofi, Medtronic/Covidien, IBM Watson Healthcare, Quest, Apple, Microsoft, Qualcomm, Facebook, Amazon, Novo Nordisk and other giants. They finally realize that Anti-Aging & Regenerative Medicine is the next generation of healthcare -the age of PRACTICAL IMMORTALITY, where lifespans of 120 to 150 in superior health may become commonplace and may be seen as early as 2029. Others such as Oracle co-founder Larry Ellison, for example, has given more than $430 million toward anti-aging research because he finds the quiet acquiescence of mortality “incomprehensible.” XPRIZE entrepreneur Peter H. Diamandis co-founded Human Longevity, which, in conjunction with StartUp Health, launched the Longevity Moonshot, whose mission is “to extend and enhance healthy life by 50+ years and change the face of aging.” Google co-founder Larry Page launched a biotech company called Calico, which aims to extend the human life span by a century. Calling it “a longer-term bet,” Page said he was confident they “can make good progress within reasonable timescales with the right goals and the right people.” PayPal co-founder Peter Thiel created Breakout Labs to fund scientists and start-ups that include some working on achieving immortality, and he invested millions in funding research to treat aging as an engineering problem to be solved at the cellular level by reprogramming cells to stop aging. The anti-aging literature is loaded with technologies to prolong lifespan by 20-40%, at least in lab animals. Interventions such as caloric restriction, rapamycin, stem cells, genetic engineering, nanotechnology and metformin, etc have been studied for decades for their anti-aging capacity. In the past several years, multiple scientific teams demonstrated the rejuvenating powers of young blood. A study published in the esteemed journal Nature found that eliminating senescent cells in aged mice boosted their lifespan by a hefty 30%. Hundreds of anti-aging drugs are now in the pipeline and billions of dollars are being expended to find real answers. The FDA finally recognized 'Aging' as a disorder that the medical community could target and potentially treat, something the American Academy of Ant-Aging Medicine (A4M) (www.Worldhealth.net, www.A4M.com) has been stating for decades. Notes A4M President Dr Ronald Klatz, "'Aging is Not Inevitable' and we are seeing the largest paradigm shift in the history of medicine." We know that lifespan has essentially been going up roughly 1 year in every 4, but healthspan is not going up at anywhere near the same rate. The United States spends 19% GDP on healthcare, most of which is used in the last 6 months of a person’s life. If you want an exciting career, the anti-aging & regenerative medicine marketplace is one to look at seriously. We can no longer practice the 'disease based' medicine of the past...preventative anti-aging & regenerative medicine is the only viable solution to prevent bankrupting of the national budgets due to massive chronic healthcare costs.
The Robots are Coming
Robotics is a rapidly emerging technology which will penetrate every aspect of business and our daily lives. This will replace massive numbers of manufacturing jobs and manual labor. Japan is expecting one in three of its population to be over the age of 65 by 2030, and one in five to be over 75, creating a major requirement for the care of the elderly. Japan is now using robots to service the elderly. A hotel opened in Japan in 2015 with lifelike robots, called 'Actroids', serving as the check-in staff. Aid assistance in nursing facilities is on the horizon, meaning many of the entry-level jobs in those areas will become obsolete just like bank tellers. Look at the field of Robotics, AI (Artificial Intelligence) and VR (Virtual Reality) technologies for massive growth industries.
Coastal Changes
Climate change will have a strong economic impact in the future. It is anticipated that by 2050, more than 40% of the world’s population will live under severe water stress, resulting in floods or drought that, combined, can put the economic value of assets at risk to record highs. Becoming efficient with resources is socially responsible and cost beneficial. Organizations need to adapt to increasing regulations controlling energy efficiency, waste, water leakage, urban congestion, transportation efficiency, land degradation, freight impact, and other factors. Allowing employees to work virtually also reduces the need for facilities and helps organizations minimize their carbon footprints.
New Energy Sources
Where we get our energy from will change dramatically. The U.S. military has pledged to get half its energy from renewable resources by 2020, and the Navy whole-heartedly believes it can turn to 50 percent biofuels by then. It makes political sense not to rely on volatile regions for energy, and this push could mean both cleaner vehicle fleets and a major bump in the competitiveness of biofuels in the market. The strangle hold that Middle Eastern oil holds will soon be an ancient memory. Biofuels and renewable clean energy are growth industries of the future..Oil and coal are on their way out.
3D Print Your Organs and Meat
3D Printable Organs are already in process via 3D “bioprint” organ tissues, a process that involves depositing a “bio-ink” made of cells precisely in layers, resulting in a functional living human tissue for use in the lab. These tissues should be better predictors of drug function than animal models in many cases. In the long-term, this has the potential to pave the way to “printing” human organs, such as kidneys, livers and hearts. By 2020, the goal is to have the technology be broadly used by pharmaceutical companies, resulting in the identification of safer and better drug candidates and fewer failures in clinical trials. ...This same 3D Printed technology via stem cells, is also being applied to meat production for human consumption. (Keith Murphy, CEO of Organovo -World Economic Forum)
World Will Get Very Small
There is major globalization shift in where business is conducted and is occurring now. McKinsey estimates that half of the world’s largest companies will be headquartered in what are now emerging markets, such as Brazil, India, and eastern European countries. Pressure from global competition and other factors resulted in over 40% of the companies that were in the Fortune 500 in 2000 falling off the list in the next several years. These were replaced largely by new global entrants and technology companies. This will continue to shift to farther parts of the planet.
The Job Skills/Info Gap
The Job Skills Gap and information Gap is the problem and not that workers are unskilled; it’s that workers don’t know what skills employers need. Technology is already disrupting existing jobs, and creating new jobs that never existed before. In fact, the top 10 in-demand jobs in 2010 did not even exist in 2004. Change is happening so rapidly that 65 percent of today’s grade school kids in the U.S. will end up at jobs that haven’t even been invented yet. If u wish to be competitive you must enhance your tech skill levels for future industries not yet mainstream. (Alexis Ringwald, Cofounder and CEO, LearnUp, -World Economic Forum)
Water as a Major Asset
Water is an asset not a liability. Driven by global population growth and rising water scarcity, the UN reports that 75 percent of the world’s available freshwater is already polluted. Under-investment in water management is exacerbating the problem, causing serious impacts on human health and the environment. A key challenge is the high capital cost, and high energy requirements, of current wastewater treatment and management systems. Desalination plants will spring up worldwide to create massive needed fresh water from sea ocean water. The ability to use biotechnology to extract resources, such as energy, from waste, and the dropping cost of industrial automation, will begin to change our approach to managing water globally. Rather than a liability, wastewater will be viewed as an environmental resource, providing energy and clean water to communities and industry, and ushering in a truly sustainable and economical approach to managing our water resources. (Matthew Silver, CEO of Cambrian Innovation-World Economic Forum)
Super Computers Replacing Your Doctor?
Supercomputers with artificial intelligence taking better care of you than your Doctor? IBM Watson has partnered with Celgene to better track negative drug side effects and IBM is applying its cognitive computing AI technology to recommend cancer treatment in rural areas in the U.S., India, and China. For example, IBM Watson could read a patient's electronic medical records, analyze imagery of the cancer, and even look at gene sequencing of the tumor to figure out the optimal treatment plan for a particular person. The IBM Watson programs are able to instantly scan the world's medical literature data for making a diagnosis and treatment plan, so in the future a nurse or tech may be able do a more detailed evaluation than even team of doctors. And coupled with advanced MRI, CT and PET scans, view the inner body in mind boggling ways and even treating cancers and other issues at the microscopic level. This will turn the medical profession on its ear. (Fortune Magazine)
The Nanobots are Coming
Nanobots (miniaturized robots as small as an atom or electron) could become commonplace and in the future, may even integrate with our brain matter allowing us to merge with computers and the 'Cloud' for a 'Singularity' or merging of our minds with machines & computers. Nanotechnology ("nanotech") is manipulation of matter on an atomic, molecular, and supramolecular scale. The earliest, widespread description of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabrication of macroscale products, also now referred to as molecular nanotechnology which is the manipulation of matter with at least one dimension sized from 1 to 100 nanometers and such technologies deal with the special properties of matter which occur below the given size threshold potential applications (including industrial and military). Governments have invested billions of dollars in nanotechnology research and can be as diverse as surface science, organic chemistry, molecular biology, semiconductor physics, microfabrication, molecular engineering, etc. The associated research and applications are equally diverse, ranging from extensions of conventional device physics to completely new approaches based upon molecular self-assembly, from developing new materials with dimensions on the nanoscale, to direct control of matter on the atomic scale. Nanotechnology may be able to create many new materials and devices with a vast range of applications, such as in nanomedicine, nanoelectronics, biomaterialsenergy production, and consumer products. On the other hand, nanotechnology raises many of the same issues as any new technology, including concerns about the toxicity and environmental impact of nanomaterials, and their potential effects on global economics, as well as speculation about various doomsday scenarios. These concerns have led to a debate among advocacy groups and governments on whether special regulation of nanotechnology is warranted..
So with nano circuitry, we may be able to live, basically, in a virtual world — Matrix style....and perhaps even Reincarnate deceased ones virtually and be able to "bring back" those lost through artificial intelligence states some scientists. By the 2030s perhaps we send nanobots into people's brains to extract memories of loved ones. Augment that with a DNA sampling of the deceased, and it may be possible to create a convincing virtual version of somebody who's passed on. This progress is so profound, that within 30 years, computational power of artificial intelligence will be a billion times that of human intelligence, allowing us to upload our minds and maybe even our very souls to a computer, leading to a form of connective 'Singularity', a term created by Google scientist Ray Kurzweil. Even Stephen Hawking thinks it's possible; "I think the brain is like a program in the mind, which is like a computer, so it's theoretically possible to copy the brain on to a computer and so provide a form of life after death," the physicist said. This may in fact lead to virtual bodies like the wild video games and Virtual Reality (VR) and Artificial Intelligence (AI) devices we seeing exploding on the scene: (PopSci.com)
Self-Driving Trucks and Cars
The push for self-driving cars is not just because motorists would rather let the machine do the work. It’s because taking humans out of equation could mean safer travel and smarter traffic flow. To look forward to how we will drive in 2020 you just have to look back to 1957. The US electricity industry ran a newspaper ad promising a life of leisure in the future with a now iconic image showing a near empty highway and a family in a self-driving car with a glass bubble roof. Instead of worrying about the road ahead, the family are doing what all families do in their downtime apparently — they play dominoes and clearly don’t have a care for skin cancer. When it comes to self-driving cars, the year 2020 doesn’t just mark a vision of the future but a deadline. Nissan and Mercedes-Benz have set 2020 down as when they plan to introduce cars that can navigate city streets without the need for a driver. Volvo, which will soon begin trialling self-driving cars in Australia, has taken that one step further. Back in 2008, Volvo’s lead safety expert Anders Eugensson predicted that “by 2020, nobody shall be seriously injured or killed in a new Volvo”. Since then, Volvo has added some fine print to that bold prediction. Volvo safety expert Trevor Rourke admitted earlier this year that “not even the Pope is infallible” but said the trend was towards zero fatalities by 2020. No matter how attentive a human driver can be, a self-automated car with lasers, radar, sonar and video sensors gives the car the edge in keeping an eye on the road. In many ways Google is leading the charge towards self-driving cars with its autonomous vehicles now having driving nearly 3 million self-autonomous kilometres with only a handful of minor accidents and most of them caused by drivers running into the self-driving car because they are distracted by the Google logo and sensors on the top. But other new players working on autonomous cars include Uber, Tesla and, if the rumours are true, Apple. As Telstra Chief Technology Officer Vish Nandlall says, we’re already down.
Driverless Trucks
Driverless trucks will be safer and cheaper than their human-controlled counterparts, but that doesn’t mean America’s 3.5 million professional truck drivers are giving up to the machines without a fight. Across the US, truckers collectively haul more than 10 Billion tons of freight each year, but it’s a tough job – the hours are long and lonely, the pay is low and the lifestyle is sedentary. In many ways it’s a job ripe for disruption; robots v truckers. “Picture the taxi drivers around the world acting in response to Uber,” says Andy Stern, the former former president of the Service Employees International Union, referring to protests and violence that erupted in many cities as the $62.5 Billion Silicon Valley on-demand ride-hailing firm challenged conventional, regulated taxis. “Truck drivers will follow a similar pattern,” says Stern. “There will be disruption in different places. You can imagine people ringing state capitals with their trucks.” Much has been written about the advent of the driverless car, with rival versions being developed by Google, Uber and Tesla, yet driverless trucks are likely to roll out at scale much sooner. “Individuals can make their own choices about whether they want to get into a driverless car or taxi, but labour-saving technology will be deployed by businesses much quicker,” explains Stern, whose book Raising the Floor explores the need for a universal basic income as technology replaces jobs. Mining giant Rio Tinto already uses 45 240-ton driverless trucks to move iron ore in two Australian mines, saying it is cheaper and safer than using human drivers. Now the race is on to put driverless trucks on public roads. In May 2015, the first self-driving truck hit the American road in the state of Nevada, and there have been several tests around the world since then including a convoy that drove across Europe to the port of Rotterdam. That convoy used a new automated driving technology called platooning, which connects trucks using Wi-Fi, sensors, GPS and cameras. The leading vehicle dictates speed and direction, while the rest automatically steer, speed up and slow down in close convoy. In San Francisco, former Googlers have launched a startup called Otto, which promises to retrofit vehicles with driverless capabilities for just $30,000. The average trucker’s wage is around $40,000 per year.
The potential saving to the freight transportation industry is estimated to be $168 Billion annually. The savings are expected to come from labor ($70 Billion), fuel efficiency ($35 Billion), productivity ($27 Billion) and accidents ($36 Billion), before including any estimates from non-truck freight modes like air and rail. It’s regulation, and not technology that stands in the way of eliminating people from behind the wheel. Although trucking companies are likely to lobby hard for the legal reform so they can save on labor, which represents an estimated 34% of operational costs per mile, Morgan Stanley conservatively estimates that the freight industry could save as $168 Billion annually by harnessing autonomous technology – $70 Billion of which would come from reducing staff. In addition to cost savings, fleets of automatedtrucks could save lives. Crashes involving large trucks killed 3,903 people in the US in 2014, according to the National Highway Traffic Safety Administration, and a further 110,000 people were injured. More than 90% of the accidents were caused at least in part by driver error. What next for drivers? Where does this leave the 3.5 million truckers whose livelihoods depend on the need for a human behind the wheel? Truck Driver is not a profession for the future.
Internet of Things
It’s the simplest of terms that is obsessing the tech industry and confusing the public: The 'Internet of Things'. There are currently 13.4 billion things connected in the world — smartphones, smart TVs, computers, tablets and the odd fridge and robotic vacuum. Juniper Research predicts that figure will reach 38.5 billion by 2020. Technology analysts Telsyte predict the number of connected devices in the average Australian home will jump from the current figure of nine to at least 24 and the internet-enabled white good will become the norm, just as smart TVs are now standard. This is another career growth area in the tech fields.
So we either prepare for these future high tech/Info tidal waves and embrace them, or be swept away by them.
Robert M. Goldman MD, PhD, DO, FAASP
Co-Founder & Chairman-World Academy of Anti-Aging Medicine
World Chairman-International Medical Commission
Co-Founder & Chairman of the Board-A4M
Founder & Chairman-International Sports Hall of Fame
President Emeritus-National Academy of Sports Medicine (NASM)
Chairman-U.S. Sports Academy’s Board of Visitors

Monday, January 9, 2017

Birth Control Pills and Depression. Is there a connection?

The ZRT Laboratory Blog

Posted by Margaret Groves on Saturday, 08 October 2016

Hormonal Contraceptives – Do They Increase Risk of Depression

shutterstock_174191402-998x666-423910-edited.jpgThere have been some articles going around the medical news reporting on a new Danish study  suggesting that hormonal contraception might increase risk of depression, and that previous studies may not have highlighted this link because they did not include women who stopped taking their birth control as a result of depressive symptoms. This study got around that problem by including in their survey women who had been using birth control at any time during the previous 6 months. So what is the fuss all about?

Findings from the study

The study did find an association between use of hormonal contraception and the subsequent use of antidepressant medications and diagnosis of depression. The risk of depression with contraceptive use decreased with increasing age, and was highest in the youngest age group studied, namely teenagers aged 15-19, than in the women aged 20-34. The authors acknowledged that antidepressants are prescribed for other reasons than depression. They also acknowledged that adolescent girls are “more vulnerable to risk factors for depression” than older women, partly explaining the higher incidence of antidepressant use in this age group.

Progestins versus progesterone

The study showed that progestin-only contraceptive products were the most likely to result in use of antidepressant medication or a diagnosis of depression. But an unfortunate confusion between progesterone and progestins was created by a statement in the introduction of the study  saying “The 2 female sex hormones – estrogen and progesterone – have been hypothesized to play a role in the cause of depressive symptoms.” This led to a claim in a popular article about this study that the authors theorized that progesterone, as well as the synthetic progestins used in hormonal contraceptives, plays a role in the development of depression.
A recent blog by ZRT’s senior research scientist and neurotransmitter expert Kate Placzek, PhD, has discussed the neuroendocrine functions of endogenous estrogen and progesterone. Briefly, sex hormones have neuromodulatory roles in brain development and neuronal plasticity, and the regulation of cognition, learning, memory, emotion, mood, and motor control. It’s understandable that mood varies at different times during the menstrual cycle as hormone levels shift dramatically and these neuromodulatory effects come into play. The blog also explains how depression can be a factor in some women, but not others, using hormonal contraception.

It’s important to understand that the study did not report the increased likelihood of using antidepressants as percentage increases, but rather in terms of a calculation of relative risk.

The study authors’ statement regarding estrogen and progesterone’s role in causing depressive symptoms cites 5 studies; however, 2 of these are only about estrogen’s effects, and 2 refer only to synthetic progestins used in oral contraceptives (not progesterone itself). The 5th was a study of experimental estrogen or progesterone replacement in a very small group of 10 women with premenstrual syndrome and 15 normal women. This study was designed only to study adverse mood symptoms in susceptible women who were prone to PMS. In the experiment, the women were first treated with leuprolide to completely suppress ovarian hormone production, and then the investigators looked at whether or not PMS symptoms returned when estrogen or progesterone was then replaced. Although they found an increase in sadness (not depression) in the women with PMS after this hormone replacement, no such increase was seen in the normal women – thus progesterone adversely affected mood only in those women who were prone to PMS. Also, since the PMS symptoms actually abated during the last week of the experimental hormone replacement, the authors stated that they couldn’t predict whether long-term or low-dose hormone treatment would result in adverse mood symptoms in women.
Adding to the confusion, another statement in the Danish study says “The addition of progesterone to hormone therapy has been shown to induce adverse mood effects in women”; yet this is referenced by 2 citations, both of which concerned a synthetic progestin, not natural progesterone.
The authors do, however, reference a review suggesting that neuroactive metabolites of progesterone, allopregnanolone and pregnanolone, can have adverse mood effects in some women as a result of modulatory effects on the GABA-A receptor, and that this can explain the effects of luteal phase levels of progesterone in women who suffer from PMS, who are particularly sensitive to such effects. This allopregnanolone paradox, known as such because it is found in some women but not the majority, was described in detail in a recent blog on PMS by Dr. Placzek.

How great is the risk of depression in hormonal contraceptive users?

At first glance, the figures seem very stark. An article on this study reported that the highest risk group, which consisted of teenage girls aged 15-19, were “80% more likely to be prescribed an antidepressant when they were on combined birth control pills and 120% more likely when they were on progestin-only pills.” However, it’s important to understand that the study itself did not report the increased likelihood of using antidepressants as percentage increases, but rather in terms of a calculation of relative risk. There is a baseline level of antidepressant use regardless of hormonal contraceptive use, and this is given a relative risk of 1.0. The teenage users of combined oral contraceptives had a calculated relative risk of 1.8, and the progestin-only pill users had a calculated risk of 2.2 compared to non-users. While these figures do represent the percentage increases in relative risk stated in the article, the statistics require more careful interpretation.
The authors also found that relative risk of depression peaked after 6 months of hormonal contraceptive use, and dropped off to a lower risk than non-users after 4 years of use. For people susceptible to such effects with hormonal contraceptives, symptoms would therefore appear relatively soon after starting use, giving the opportunity to switch to a different preparation or method of contraception.

Conclusion

This is an important study to add to others in the literature that have looked at depression associated with use of hormonal contraceptives, and a risk of depression, especially in teenagers, is certainly of concern. However, hormonal methods are overwhelmingly very safe and effective, and practitioners should weigh the pros and cons of each method of contraception when advising patients. Some women may be susceptible to adverse effects on mood, while others may not. The pros and cons of an unwanted pregnancy must also be weighed against any potential drawbacks to using an effective means of contraception.

Tuesday, November 1, 2016

The #1 Contributor to Better Health and Wellness

Oh my.....this is an article of a different kind.

I've had this topic on my mind for some time now and finally found the time to sit down and gather some thoughts and clinical evidence to help people in realizing what the BIGgest contributor to better health and wellness is.  In any given day, I respond to countless questions and sit down in private consultations reviewing health histories, lab values, family diseases, medications, supplements, and the like.  However, as I work with an individual, I'm always keenly in tune to something that is more important than any custom therapy or regimen that I could design for them.  It's not something that I create and dispense in a bottle, but it far surpasses anything on the pharmacy shelves when it comes to overall health, sense of wellness, and success in achieving a goal.  So what is it?  (I'm glad you asked)

Actually the question is not, "what is it?"but instead, "who is it?"  Humans are complex social creatures often defined by family, language, culture, nationality, religion, race, or perhaps even trade.  We are born into some of these groups, but we can choose to join others. Did you know that our PURPOSE is very much intertwined with the people we interact with (or perhaps those we choose not to interact with)? Scientific study results show that a higher level of purpose in life, through our personal associations, is associated with better health, increased participation and productivity, better socioeconomic status, and better outcomes for persons with addiction.  Even patients with Alzheimers were reported to have better cognitive function, despite their disease, when surrounded by positive people and purpose. In other words, your social network could be thrusting you forward, or pulling you down.  Now hold on, I'm not suggesting that you dump all of your friends, but I am suggesting that you pay attention to those that make you feel joy, strength, positive, at ease, and purposeful about life.  This important health contributor alone can make or break you. Literally!

Now let me touch on some specific details and evidence....

Weight Loss Success
When it comes to weight loss coaching, I'm very strategic to cover social networks with an individual.  In a published study of over 12,000 people followed for over 30 years, here's what the results showed. "A person's chances of becoming obese increased by 57% (95% confidence interval [CI], 6 to 123) if he or she had a friend who became obese in a given interval. Among pairs of adult siblings, if one sibling became obese, the chance that the other would become obese increased by 40% (95% CI, 21 to 60). If one spouse became obese, the likelihood that the other spouse would become obese increased by 37% (95% CI, 7 to 73)"  The bottom line is that, those people in your social network can propel you to your weight loss goal, or they can inhibit you in your success.  If you want to be successful at weight loss, make sure you have your family and friends on board with you. We all know it's a real drag to watch the family eating pizza and sugar donuts while we're up to our greens in leaf lettuce. So not fair right?

Family Dynamics 
 Basic family dynamics can have an overall impact on health.  It has been known for many years that marriage increases life expectancy, especially in men. Family stability also helps adolescents avoid poor lifestyle decisions and children in a stable and loving home have a better chance at doing well in their life goals.  I've always followed and parented by the standard that "our children only have ONE chance at a happy childhood." If they feel engaged, loved, and a sense of belonging to that family unit, they will do "life" much better. The family circle of influence can be very healthy, or very unhealthy.

Religious services
There's evidence supporting longer life expectancy in those that regularly attend religious services compared to those who rarely or never do. According to data published in 1999 this can translate into a seven-year difference in life expectancy.  This does not mean that private spirituality is not beneficial, but that social group gathering and interaction with others is healthy all the more.  Faith and purpose go hand in hand.  It's healthy!


Your team
If you are a professional, a leader, or in business here's a big secret to success and 'purpose' in what you are doing.  Make sure to line up the "who" before you chase the "what". In the book Good to Great, Jim Collin's leading point is that you need the right people on the bus before you decide where to take the bus.  People are not your greatest asset.  The RIGHT people (your team) are your greatest asset! Real success takes more than just YOU to get where you want to go.  Everyone can feel purpose when you're all on the same page and working towards a common goal.  It's healthy!

All-IN
You can ask those in 'my circle' about this personal attribute deep inside me.  If I'm in, I'm All-IN.  I choose my social network very carefully these days (disclaimer...it wasn't always that way).  There's nothing so healthy as being surrounded by personal connections or a 'community' where everyone is genuinely concerned about the group's health, but even more importantly, concerned about each of the individuals that make up the group.  If you feel consistently drained by a certain someone(s) inside a circle of influence, then maybe it's time to step back and evaluate the impact on you, your health, and your goals to achieve success.  It's healthy to do so!



This is not my typical blog on hormones, supplements, testing, etc. but it is so, so, so important to overall health.  If you are working at your best in the physiological areas and missing the link in social and emotional areas, then you're going to be sub-optimal in your quest to achieve better health.  Evaluate your purpose today and figure out what,  I mean who, is in the benefit column and who is in the deduction column.  Hopefully the positives will far outweigh the negatives.


All the best,

Dr. Sonja

Wednesday, July 6, 2016

Hormone Health in Men

                                                            

Andropause: Real Men Go For Balance           

ThinkstockPhotos-484918688.jpg
The first thing a man entering andropause generally notices is a subtle downward shift in strength and energy as hormone levels taper off. Muscle tone and stamina are the first to go and he starts to gain weight and that "spare tire." He may also develop a voracious appetite and food cravings he never had before. As symptoms kick in at mid-life, hormone testing can identify hidden imbalances that complicate symptoms of andropause and contribute to rapid aging.

The 2006 HIM Study found that nearly 40% of US males over 45 years old had low testosterone levels (an estimated 13 million US males), however the majority of men in the study did not recognize that the weight gain, sore muscles, lack of libido, insomnia, and burnout they were experiencing could have something to do with andropause and hormone imbalance – instead they put their symptoms down to "just getting old."
Getting old was the recurrent theme at a recent 50th birthday party I attended where non-stop over the hill jokes and "low-T" lamentations were heaped upon the birthday boy. All that talk of testosterone reminded me of an article in Atlantic magazine a few years ago that slammed the drug industry’s promotion of supplemental testosterone as "god's gift to men," and questioned whether every modern man really needs testosterone?
One way to begin to answer that question is to start with physiology and understand that the androgens (primarily testosterone and DHEA) in their natural state bestow the heavier bone and muscle mass, deeper voice, drive and virility we associate with the male of the species. And that when they start to decline around the age of 45, the average Joe will experience some of the following symptoms:
  • Decreased strength/stamina/endurance
  • Decreased muscle mass/sore muscles
  • Weight gain in the hips, thighs, waist, and/or breasts
  • Increased body fat
  • Poor recovery from exercise
  • Burnout and fatigue
  • Lack of mental clarity
  • Decreased sex drive and/or competitive drive
  • Prostate problems
The natural decline of hormone levels in aging men also poses an increased cardiovascular risk which is where the controversy over replacement therapy comes in: whether it can hurt or help healthy men, and those who already have heart disease. It's an important question, particularly in light of the skyrocketing numbers of men using testosterone products to feel better and to increase muscle mass and energy. According to the FDA, the use of testosterone therapies increased from 1.3 million patients in 2009 to 2.3 million patients in 2013, a doubling of prescriptions in less than five years. In light of these numbers and that the risks vs. benefits of androgen supplementation in men have not been clearly identified, the Atlantic article raised some important questions, for which recent research has some good answers.

If the need is clearly established and monitored through hormone testing, supplementing testosterone can be beneficial.

Replacement has its place

In a 2015 study of 1472 generally healthy men between the ages of 52 and 63 with no history of heart disease, researchers found that those who received testosterone supplementation to achieve normal levels did not increase their risk of heart attack stroke or death but actually showed a reduction of risk compared to patients not on testosterone therapy. Even more good news came in a follow-up study this year (2016) of 755 male patients between the ages of 58 and 78, all with severe coronary artery disease. Researchers found that the men who received testosterone therapy as part of their follow-up treatment fared much better than those who didn't. In fact, the non-testosterone therapy patients were 80 percent more likely to suffer an adverse event.

Its always about balance

Aging is inevitable and dropping hormone levels go with the territory, but what is not inevitable, is how rapid or steep the decline in hormones needs to be. Whether men age well, or rapidly, depends a great deal on their stress levels, diet, exercise, alcohol intake, weight gain etc. For example, the more overweight the man, the more estrogen he will churn out in his fat cells, creating a surplus in relation to waning testosterone, and a raft of estrogen related symptoms, like moodiness, depression, and female pattern of weight distribution in the hips, thighs, and breast tissue. (A fact that should not be lost on those concerned about prostate health is that estrogen is a growth hormone linked with the development of prostate cancer.)
Experts in the field of hormone testing and balance, like Dr. David Zava, owner of ZRT Laboratory will tell you that where the need is clearly established and monitored through testing, supplementing with testosterone can be beneficial, particularly, when used in tandem with a healthy lifestyle.

Men in balance do these things during andropause

  • *Test their hormone levels to detect and correct imbalances linked to symptoms.
  • Follow up with a natural hormone friendly physician
  • Lose weight as needed. Fat cells contain aromatase, an enzyme that robs the male body of available testosterone by converting it into estrogen.
  • Stick with a program! A low glycemic Mediterranean style diet that's high in protein and fiber and low in fat and carbs can help rebalance hormones and assist weight loss
  • Throw out testosterone robbers like caffeine, alcohol, cigarettes, and unnecessary stressors like burning the candle at both ends day in and day out etc.
  • Take up strength training or weight bearing exercise to boost testosterone and DHEA levels naturally by building up lean muscle mass
  • Counteract stress (the higher the stress levels, the lower the testosterone) with regular exercise – 45 minutes is optimal but even 10 mins. 3x a day adds up to 30 minutes and that is GOOD
  • St-r-e-t-c-h and breathe deep to release tension held in the muscles and lower stress hormones that deplete T levels
  • Hit the sack earlier – less than 7 hours of sleep disrupts appetite hormones to increase cravings and feelings of hunger
  • Take time to do the things you enjoy! Stress reduction is the key to normalizing cortisol and T levels   
*Topical supplements rubbed into the skin (gels, creams) do not always show up in a serum test and can lead to possible OVER supplementation. This is why so many physicians test hormone levels in saliva or dried blood spot sampling to track and adjust dosage as needed.

The good andropause

I encourage you to read the Atlantic article with the awareness that hormone balance never boils down to just one hormone! Getting to the land of optimal health and aging is about getting ALL key players – estrogen, progesterone, testosterone, DHEA, cortisol, thyroid – working together in sync! Just like the symphony orchestra, if one instrument is out of tune, so goes the melody…hormones are your internal symphony.  Replacement has its place as long as it is in tune with your body’s natural rhythms and need for proper care, feeding and rest during andropause!

ZRT Laboratory BLOG Posted by Candace Burch

Monday, April 25, 2016

RSVP-ASAP!!! MAY 2016 YOUniversity Session "Cosmetic and Aesthetic PRP Therapy"

The YOUniversity sessions have been a BIG hit.

Last month's HORMONE's and HEALTH session was a packed house and we want to continue with more information on what's happening inside Providence Medical Spa. Our multi-disciplinary team of healthcare and aesthetic professionals is committed to bringing you the best and most current advancements in Anti-Aging, Skin, and Wellness Care.  The list of services continues to grow and expand as we respond to the requests of clients seeking various options in their anti-aging healthcare journey.

 *****PRP (Platelet Rich Plasma) is the latest addition to the line-up of services inside the MedSpa and we want to offer YOU an invitation.

PRP Therapy?!?!   Really?!?!  That's right!!  NOW available in Branson MO at Providence Medical Spa. It is our pleasure to tell you ALL about PRP by hosting another YOUniversity event.

What is PRP? 
What can it do for your collagen production and the appearance of your skin? 
What does it cost to have it done? 
Are there other options to go along with PRP? 
What can you expect?



This is your invitation to get a behind the scenes look at PRP along with all of the other services our team provides inside the MedSpa.

 Is it time for a Hydrafacial
Are you interested in hormone testing and bio-identical hormones
Do you want an individualized vitamin and supplement regimen because you're just not sure what to take?
Do you want to have a skin tightening session with the Venus machine?
Have you been wanting eyelash extensions or permanent make-up

Providence has it ALL!!  Come check us out by attending this FREE event inside the Spa Conference Room.   See details below and get registered by calling 417-334-4032
 
Join us May 12th, 2016 @6pm

 Make plans, bring a friend, but remember to RSVP-ASAP!  Our team wants to be prepared for your arrival with resources and information to answer all of your questions.

......and HINT HINT….we give discounts and special offers to those that attend these special programs.  We hope you can join us at the next YOUniversity!








Thursday, April 14, 2016

Testing Hormones 101

Saliva Testing of Hormones and Cortisol
Estrogens, progesterone, testosterone, DHEA-S and cortisol are routinely measured in saliva. Steroid hormones in the bloodstream are mostly (95-99%) bound to carrier proteins, and in this form are unavailable to target tissues. Only the unbound fraction freely diffuses into tissues, including the salivary gland. Hormone levels in saliva therefore represent the quantity of the hormone that is currently available to target tissues and actively exerting specific effects on the body.



http://youtu.be/KURpZSXA7u8


Often I'm asked how to go about testing for hormonal imbalance.  It's so simple and affordable and such a life changer for those struggling to make it through their days.  And if you can't make it through your days, how will you ever make it through your years?  Simply click on the link above to find out more about the testing kit that I can provide conveniently by shipping it to your home address. The same kit is used for both women and men and a simple call to our staff can help you determine which testing panel is best for you and your symptoms.  417-231-4544

So is Hormonal Imbalance Affecting You?  If you see any correlating symptoms to what you are personally experiencing, it's probably a good idea.

Infertility
Loss of pregnancy/miscarriages
Erectile Dysfunction
Irritability
Anxiety
Night sweats
Incontinence
Fibroids
Sexual dysfunction
Insomnia
Fatigue
Difficulty losing weight or gaining unexplained weight
PMS
Vaginal Dryness
Yeast Infections
Continual infections and immunity issues
Palpitations
Migraines
Memory concerns
Lack of focus
Loss of stamina
Loss of muscle mass
Feeling intensely agitated
Bloated
And more.......




 Don't put testing off another day.  What you have accepted as "normal" may not be "optimal" for your health, wellness, vitality, and longevity. 
Let's test and assess your individual needs.  For  private appointments 417-334-4032

 To your good hormone health,
Dr. Sonja